Brown Fat Cells Activation Helps Fight Obesity

Researchers have found that the role of brown fat cells inactivation of metabolism increase and the accumulation of Bace1 might help reduce the obesity among the general population. So, let discuss the Brown fat cells activation helps fight obesity in details below:

Here, the detailed information about Brown fat cells activation helps fight obesity:

Brown fat cells activation helps fight obesity


Obesity is a serious condition that is claiming more and more people. Every year, almost over a thousand people are included in the obese category including children, young adults and people over the age of 40.

Who is Obese?

The question that is asked by many people is, what is obese and while the signs may be clear physically with overwhelming body fat and weight, Obesity starts earlier. When a person crosses the upper threshold of their BMI (Body Mass Index) range. They are considered overweight and obese.

Reason leading to Obesity

There are a lot of reasons that might lead to obesity including genetic heredity, inconsistent and monotonous lifestyle, unhealthy food and diet, inactive routine and stress and other health problems. Obesity itself might be considered a disease of a kind as it leads to heart problems, diabetes, and inactivity. Mostly physicians and doctors try to resolve the obesity issue by recommending exercise and diet changes but that does not work for everyone, especially people who have inherited it. There have been some major breakthroughs that have been helpful in pinpointing the cause of obesity. Identifying the cause of the disease help in modifying that causing factor which could help in the reduction of that condition.

Obesity and Brown Cells

The researchers at Max Planck Institute for Metabolism Research and the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD) at the University of Cologne have been at that very mission. In an ongoing experiment, they have been successful in inhibiting a protein that hinders the activation of the brown fat cell from mice. Supposedly, there are two kinds of fat cell in the body. White fat cells help in the accumulation of the fat while brown fat cell helps in the burning of fat through increased metabolism. It has been found that obese people have a low brown fat quotient which explains the lack of metabolism and hence the obesity.

Role of Bace1

According to the research teams led by Dr. Jan-Wilhelm Kornfeld and Professor Jens C. Brüning from the Max Planck Institute for Metabolism Research and CECAD, there is an inhibitor in the body of humans. Mice and a lot of other mammals called microRNAs and are also known as “off switches”. One of their vital roles in controlling the activation of the brown cells. The researcher observed there microRNAs closely in mice for months when they finally isolated a microRNA called the miR328 in the fat of the obese mice. The reduced profusion of miR328 in the fat cells of mice inhibit the control of a protein called Bace1. The amount Bace1 was found to be present in increased in the brown adipose tissue of obese mice which led to the assumption that the accumulation of Bace1 in brown fat cells causes the increase of obesity. The goal for the researcher has been developing inhibitors for Bace1 which was seen to be very effective in activating the brown fat cells. This leads to a reduction in the accumulation of fat.

Ask Your Doctor about Bace1

Also, check Bace1 and brown fat cells in the Journal of Medical Health and CDC official website. You can know about your metabolism and any Bace1 enhancing medication by chat with doctor online from our website Just Health Experts or healthcare specialist to find out more about the role of brown fat cells in obesity. 

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